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Detlef Schuppan Selected Research

Subtilisins (Subtilopeptidase A)

1/2019Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo.
1/2016Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease.

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Detlef Schuppan Research Topics

Disease

95Fibrosis (Cirrhosis)
04/2022 - 02/2002
65Liver Cirrhosis (Hepatic Cirrhosis)
10/2022 - 04/2000
49Neoplasms (Cancer)
06/2022 - 02/2002
46Celiac Disease (Celiac Sprue)
10/2021 - 03/2003
44Inflammation (Inflammations)
04/2022 - 12/2002
24Liver Diseases (Liver Disease)
01/2022 - 12/2004
21Hepatocellular Carcinoma (Hepatoma)
02/2021 - 02/2002
17Non-alcoholic Fatty Liver Disease
10/2022 - 04/2009
12Hepatitis C
12/2020 - 12/2002
12Chronic Hepatitis C
03/2017 - 07/2005
9Fatty Liver
04/2022 - 04/2009
9Liver Neoplasms (Liver Cancer)
01/2020 - 10/2005
7Insulin Resistance
01/2022 - 12/2011
6Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
11/2021 - 04/2006
6Colitis
10/2021 - 09/2006
5Cicatrix (Scar)
01/2022 - 08/2002
5Genetic Predisposition to Disease (Genetic Predisposition)
11/2021 - 01/2009
5Autoimmune Diseases (Autoimmune Disease)
01/2021 - 11/2002
5Neoplasm Metastasis (Metastasis)
01/2020 - 06/2004
5Atrophy
01/2019 - 04/2006
5Chronic Hepatitis B
01/2018 - 03/2004
5Melanoma (Melanoma, Malignant)
01/2018 - 02/2002
4Portal Hypertension
11/2022 - 05/2014
4Alcoholic Fatty Liver
04/2022 - 07/2010
4Wheat Hypersensitivity (Wheat Allergy)
02/2021 - 09/2013
4Type 2 Diabetes Mellitus (MODY)
01/2020 - 12/2016
4Hemochromatosis (Bronze Diabetes)
09/2005 - 03/2003
3Weight Loss (Weight Reduction)
01/2020 - 12/2011
3Porphyria Cutanea Tarda
01/2019 - 02/2002

Drug/Important Bio-Agent (IBA)

40Glutens (Glutelin)IBA
11/2021 - 10/2003
29Biomarkers (Surrogate Marker)IBA
11/2022 - 04/2000
27CollagenIBA
01/2022 - 02/2002
23Proteins (Proteins, Gene)FDA Link
02/2021 - 12/2002
20EnzymesIBA
04/2022 - 12/2002
13Peptides (Polypeptides)IBA
01/2021 - 02/2002
12Protein Glutamine gamma Glutamyltransferase 2IBA
11/2021 - 03/2003
12CytokinesIBA
01/2020 - 02/2002
11Antiviral Agents (Antivirals)IBA
01/2018 - 01/2006
11Matrix Metalloproteinases (MMPs)IBA
01/2011 - 06/2003
10Carbon Tetrachloride (Tetrachloromethane)IBA
04/2021 - 06/2010
9Trypsin InhibitorsIBA
10/2021 - 12/2012
9AmylasesFDA Link
10/2021 - 12/2012
9Thioacetamide (Thioacetamid)IBA
04/2021 - 06/2006
9Messenger RNA (mRNA)IBA
01/2019 - 03/2005
8Pharmaceutical PreparationsIBA
04/2022 - 07/2003
7AntibodiesIBA
10/2022 - 02/2002
7ProcollagenIBA
10/2019 - 07/2005
7AutoantibodiesIBA
01/2019 - 02/2002
7Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2019 - 04/2005
6Immunoglobulin A (IgA)IBA
11/2021 - 01/2006
6AutoantigensIBA
11/2021 - 10/2003
6Phosphotransferases (Kinase)IBA
02/2021 - 05/2007
6HLA-DQ8 antigenIBA
07/2020 - 11/2009
6Antifibrotic AgentsIBA
01/2018 - 04/2000
6Biological ProductsIBA
01/2017 - 04/2008
6Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2010 - 04/2003
5LipidsIBA
04/2022 - 12/2011
5Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2022 - 01/2008
5RNA (Ribonucleic Acid)IBA
01/2021 - 01/2004
5Toll-Like Receptor 4IBA
07/2020 - 12/2012
5Small Interfering RNA (siRNA)IBA
01/2020 - 01/2009
5Hyaluronic Acid (Hyaluronan)IBA
03/2017 - 03/2004
5InterferonsIBA
03/2017 - 12/2010
4Immunoglobulin G (IgG)IBA
10/2022 - 11/2005
4InterleukinsIBA
01/2022 - 12/2010
4Complement C3 (C3 Complement)IBA
01/2022 - 02/2015
4Immunoglobulin E (IgE)IBA
10/2021 - 11/2017
4AllergensIBA
10/2021 - 01/2017
4Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
02/2021 - 12/2004
4Methionine (L-Methionine)FDA Link
01/2020 - 11/2014
4Monoclonal AntibodiesIBA
01/2020 - 04/2003
4Triglycerides (Triacylglycerol)IBA
11/2019 - 06/2010
4AntigensIBA
01/2019 - 04/2006
4IronIBA
01/2019 - 06/2005
4anti-transglutaminase autoantibodyIBA
12/2018 - 01/2006
4Ribavirin (Virazole)FDA LinkGeneric
01/2012 - 08/2005
4Histone Deacetylase InhibitorsIBA
09/2007 - 02/2002
4ErbB Receptors (EGF Receptor)IBA
08/2006 - 12/2004
4Interferon-alpha (Interferon Alfa)IBA
06/2006 - 12/2002
3Collagen Type VIIBA
01/2022 - 12/2020
3Sorafenib (BAY 43-9006)FDA Link
02/2021 - 05/2007
3Antineoplastic Agents (Antineoplastics)IBA
02/2021 - 05/2006
3Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA
01/2020 - 04/2016
3Choline (Choline Chloride)IBA
01/2020 - 01/2016
3sodium sulfate (sodium bisulfate)FDA LinkGeneric
01/2020 - 08/2012
3Glucagon-Like Peptide 1 (GLP 1)IBA
01/2020 - 04/2012
3Alanine Transaminase (SGPT)IBA
01/2020 - 01/2011
3Hydroxyproline (4 Hydroxyproline)IBA
01/2020 - 05/2011
3Dextrans (Dextran)FDA Link
01/2020 - 08/2012
3Transaminases (Aminotransferases)IBA
11/2019 - 08/2005
3EpitopesIBA
01/2019 - 10/2014
3AcidsIBA
01/2019 - 11/2016
3CholesterolIBA
01/2019 - 05/2003

Therapy/Procedure

63Therapeutics
11/2021 - 12/2002
12Gluten-Free Diet
11/2021 - 04/2006
9Ligation
04/2021 - 03/2008
8Liver Transplantation
10/2019 - 07/2003
7Immunotherapy
06/2022 - 07/2016
4Aftercare (After-Treatment)
09/2017 - 01/2004
4Radiofrequency Ablation
01/2016 - 10/2003